Page 6 - Health Sciences
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Health Sciences







                                                              The epidemiological and clinical importance of bone
                                                              metastasis has long been recognized, but the past
                                                              decade has seen an explosion in the fields of bone
                                                              biology and bone cancer research. This period of time
                                                              has been marked by a number of key discoveries that
                                                              have led to the opening up of entirely new areas for
                                                              investigation as well as new therapies which combine
                                                              surgery and biological therapeutic approaches.

                                                              Bone is a common site of cancer metastases - cancer
                                                              cells commonly develop in bone and spread to other
                                                              organ systems through the bloodstream. For example, the
                                                              incidence of bone metastases in breast and prostate
                                                              cancers is 70%, whereas it is only 30 to 40%in metastatic
                                                              lung cancer. In clinical terms, bone metastases have
                                                              substantial negative effects on a patient's quality of life
                                                              and are a main cause of patient mortality.

                                                              Given the global prevalence of breast and prostate
                                                              cancers, knowledge of bone biology has become
                                                              essential for the medical and cancer research
                                                              communities. This book provides, all in one resource, the
                                                              most recent data on bone cancer development
                                                              (cellular and molecular mechanisms), genomic and
                                                              proteomic analyses, clinical analyses (histopathology,
                Bone Cancer: Progression and                  imaging, pain monitoring), as well as new therapeutic
                Therapeutic Approaches                        approaches and clinical trials for primary bone tumors
                by Dominique Heymann Publisher:               and bone metastases.
                Academic Press, 2009                             Presents a comprehensive, translational source for all
                Edition: Hardcover                               aspects of bone cancer in one reference work
                ISBN is 9780123748959                            Bone cancer experts (from all areas of research and
                                                                 practice) take readers

                                                                 from the bench research (cellular and molecular
                                                                 mechanism), through genomic and proteomic analysis,
                                                                 all the way to clinical analysis (histopathology and
                                                                 imaging) and new therapeutic approaches.
                                                                 Clear presentation by bone biologists of the cellular
                                                                 and molecular mechanisms underlying bone tumors
                                                                 and bone cancer metastasis as well as the genomic
                                                                 and proteomic assays used in detecting cancer within
                                                                 given organ systems
                                                                 Clear presentation by oncologists and radiologists of
                                                                 how histopathology, imaging, and pain monitoring can
                                                                 lead to new therapeutic approaches





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